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CF Support Scientific Review


Natural therapeutic approach:
CF Support for chronic fatigue syndrome
NatCell® CF Support is a blend of adrenal and mesenchymal cell extracts

Adrenal extract to support the hypothalamus-pituitary-adrenal axis

    · Adrenal extract derived from the gland of mammals has a long history of use as a booster for adrenal functions. Originally administered in an injectable form along with vitamins, it is now more conveniently available for oral administration. Animal studies have shown that both forms have comparable activities (Craveri, 1971). Adrenal extract acts by supplying a small amount of adrenal hormones and factors that promote an improved adrenal function.

    · The adrenals are little triangular-shaped glands located on top of each kidney (Mg. 2).

Figure 2. The Adrenal Glands

Adrenal Galand & Pituitary Gland Diagram

    The inner part of the adrenal, called the medulla, produces epinephrine (adrenaline) that is directly involved in the "fight or flight" response to a perceived danger. Epinephrine raises pulse rate, blood flow and blood sugar. The outer part of the adrenal, called the cortex, secretes three major corticosteroids: 17-ketosteroids (DHEA), mineralocorticoids (aldosterone) and glucocortocoids (cortisol and corticosterone). These hormones have diverse functions in the body. Androgen precursors such as DHEA have anti-inflammatory and growth-promoting functions and are believed to have anti-aging properties in both men and women. Aldosterone controls sodium excretion by the kidney to maintain blood volume and blood pressure. Cortisol is the most potent glucocorticoid produced by the adrenal. It is structurally derived from cholesterol (Fig. 3) and acts on specific receptors

Figure 3. Chemical Structure of Cortisol

Chemical Structure of Cortisol

throughout the body to influence glucose homeostasis, fat and CH20H protein metabolism, immune cortisel I function, vascular tone and bone metabolism.   It also has potent anti-inflammatory effects. As mentioned before, cortisol secretion is controlled through the HPA axis via ACTH secretion by the pituitary gland.   Cortisol secretion is subjected to cireadian variations with peaks in the early morning and at night. Cortisol can also be triggered in situation of physical and psychological stresses.

In CFS, the adrenal can still produce minimal levels of these hormones but the normal circadian rhythm of cortisol secretion is disrupted and the adrenal reserve is low (MacHale, 1998).  As a consequence, the depleted adrenal cannot respond adequately to any stressful situation whether physical or psychological.  Adrenal depletion results in reduced physical and emotional resistance as well as general exhaustion and weakness. Supplementing with adrenal extract may stimulate a sluggish gland by providing the little hormonal kick needed to step back in the right gear.

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